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Chemicals
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فتح في المتصفح →WEEE: evidence and national protocols guidance
How to issue evidence, meet and report on recovery and recycling targets and apply protocols on waste electrical and electronic equipment (WEEE).
IMO treaty on hazardous and noxious cargo to enter into force in 2027
The 2010 HNS Convention enters into force on 29 November 2027, establishing the first comprehensive international liability and compensation regime for maritime transport of hazardous and noxious substances. Shipowners must maintain certified insurance; an HNS Fund capped at 250 million SDR provides additional compensation financed by post-incident cargo receiver contributions, covering over 2,000 substances including chemicals, oils, LNG, and LPG.
No-Migration Variance From Land Disposal Restrictions for Clean Harbors Grassy Mountain, Utah
The Environmental Protection Agency (EPA) is approving with conditions, no-migration variances for four categories/groups of wastes, containing up to a combined 250 temporary disposal units ("put piles") at any one time, from the Resource Conservation and Recovery Act (RCRA) Land Disposal Restrictions (LDR) standards at Clean Harbors' Grassy Mountain (Clean Harbors) commercial treatment, storage and disposal facility (TSDF) in Tooele County, Utah. These variances will allow Clean Harbors to temporarily store treated hazardous wastes that are awaiting LDR compliance verification in put piles within its Subtitle C (hazardous waste) landfill. The petitioner demonstrated, to a reasonable degree of certainty, that there will be no migration of hazardous constituents from the put piles for as long as the wastes remain hazardous. Additionally, once LDR compliance is verified, the put piles will be disposed within the onsite RCRA hazardous waste landfill cell and will be subject to the conditions set out in the Compliance Monitoring Plan section of this document.
Certain New Chemicals; Receipt and Status Information for February, March, and April 2026
This document announces the Agency's receipt of new chemical submissions under the Toxic Substances Control Act (TSCA), including information about the receipt of a Premanufacture Notice (PMN), Significant New Use Notice (SNUN), Microbial Commercial Activity Notice (MCAN), and an amendment to a previously submitted notice; test information; a biotechnology exemption application; an application for a test marketing exemption (TME); and a notice of commencement of manufacture (defined by statute to include import) (NOC) for a new chemical substance. This document also provides a periodic status report on the new chemical substances that are currently under EPA review or have recently concluded review. EPA is hereby providing notice of receipt of this information, as required by TSCA, and an opportunity to comment. This document covers new chemical submissions that have passed an initial screening and, for PMNs, SNUNs and MCANs, were determined to be complete during the period from 04/1/2026 to 04/ 30/2026 regardless of initial submission date.
Color Additives
21 CFR Part 70 establishes federal regulations governing color additives used in foods, drugs, and cosmetics under the Federal Food, Drug, and Cosmetic Act. The regulation defines color additives as dyes, pigments, or synthetic substances capable of imparting color when added to food, drugs, cosmetics, or the human body, and clarifies exemptions for natural food ingredients and substances where color is incidental to primary function. The FDA's Color Certification Branch administers certification procedures for regulated color additives.
Listing of Color Additives Subject to Certification
21 CFR Part 74 establishes regulations for certified color additives used in food, including dietary supplements. The regulation specifies identity requirements, purity specifications, permissible uses, and labeling standards for FD&C Blue No. 1 and FD&C Blue No. 2. These synthetic dyes must meet strict composition and contamination limits for volatile matter, impurities, heavy metals (chromium, manganese, arsenic, lead), and total color content, and all batches require certification per 21 CFR Part 80.
Dietary Supplements That Present a Significant or Unreasonable Risk
This regulation designates dietary supplements containing ephedrine alkaloids as adulterated products under the Federal Food, Drug, and Cosmetic Act because they present an unreasonable risk of illness or injury under recommended or ordinary conditions of use.
Good Laboratory Practice for Nonclinical Laboratory Studies
21 CFR Part 58 establishes Good Laboratory Practice (GLP) standards for nonclinical laboratory studies supporting FDA applications for regulated products including drugs, medical devices, biologics, food and color additives, and electronic products. The regulation ensures quality and integrity of safety data submitted under the Federal Food, Drug, and Cosmetic Act and Public Health Service Act by defining requirements for test articles, control articles, study scope, and application types covered.
Listing of Color Additives Exempt from Certification
21 CFR Part 73 establishes permitted color additives exempt from FDA certification for food use, including diluents in color additive mixtures. It specifies GRAS substances and approved diluents for general food coloring, marking food supplements and produce, and coating shell eggs, with detailed specifications for substances like annatto extract including limits on arsenic and lead contamination.
Indirect Food Additives: Adhesives and Components of Coatings
21 CFR Part 175 establishes safety standards for indirect food additives used in adhesives and coatings that contact food through packaging. Adhesives may be safely used in food packaging if they contain approved substances, remain separated from food by a functional barrier or meet contact limits, and are properly labeled. Pressure-sensitive adhesives for labels and tapes on poultry, dry foods, and processed fruits/vegetables must be formulated from safe substances or prior-approved components, with specified limits on antioxidants, optical brighteners, and photoinitiators.
Substances Generally Recognized as Safe
21 CFR Part 182 establishes FDA regulations for substances generally recognized as safe (GRAS) for use in food. The regulation defines GRAS status, outlines good manufacturing practice requirements including quantity restrictions and food-grade purity standards, and lists approved food ingredients such as spices, essential oils, natural extractives, and synthetic flavoring substances that may be used in accordance with the established guidelines.
Indirect Food Additives: Adjuvants, Production Aids, and Sanitizers
21 CFR Part 178 establishes regulations for indirect food additives used as adjuvants, production aids, and sanitizers. It permits hydrogen peroxide solution (max 35% by weight) to sterilize food-contact polymeric surfaces with residue limits not exceeding 0.5 ppm, and allows sanitizing solutions containing hypochlorite compounds on food-processing equipment and utensils, subject to adequate drainage before food contact.
Food Additives Permitted for Direct Addition to Food for Human Consumption
21 CFR Part 172 establishes regulations for food additives permitted for direct addition to human food. The regulation prescribes general provisions requiring additives be used only in quantities necessary to achieve their intended effect and meet food-grade standards. Subpart B details specific approvals, including anoxomer (CAS 60837-57-2), a polymeric antioxidant permitted for use in fats and oils up to 5,000 ppm, subject to defined purity, molecular weight, and heavy metal specifications.
Mitigation Strategies to Protect Food Against Intentional Adulteration
21 CFR Part 121 establishes mitigation strategies to protect food against intentional adulteration. It applies to domestic and foreign food facilities that manufacture, process, pack, or hold food for U.S. consumption and are required to register under the Federal Food, Drug, and Cosmetic Act. The rule defines key terms including actionable process steps, food defense, contaminants (biological, chemical, physical, or radiological agents), and verification/monitoring requirements to ensure mitigation strategies operate as intended.
Food Additives Permitted in Food or in Contact with Food on an Interim Basis Pending Additional Study
21 CFR Part 180 establishes the regulatory framework for interim approval of food additives and food-contact substances when new safety or functionality concerns arise but evidence does not conclusively prove harm. Interim regulations permit continued use during study periods, subject to specified limitations, mandatory progress reporting every six months, and compliance with good laboratory practice standards. The FDA may revoke interim approvals if adequate studies are not initiated within 60 days or if interim results indicate health hazards.
Indirect Food Additives: Polymers
21 CFR Part 177 establishes safety standards for acrylic and modified acrylic plastics used in food contact applications. The regulation permits semirigid and rigid acrylic polymers as articles or components in contact with food, provided they contain at least 50% polymer units from specified acrylic or methacrylic monomers. Optional additives include GRAS substances and approved compounds; specific monomers and copolymers are listed, with restrictions on minor monomers for repeated-use articles only.
Indirect Food Additives: Paper and Paperboard Components
21 CFR Part 176 establishes safety standards for indirect food additives used as components in paper and paperboard intended for food contact. The regulation permits specific substances—including acrylamide-acrylic acid resins, alkyl ketene dimers, anti-offset agents, chelating agents, and chromium complexes—for use in paper manufacturing under defined conditions and concentration limits to prevent chemical migration into food while maintaining packaging performance.
Food Additive Petitions
21 CFR Part 171 establishes procedural requirements for petitions requesting approval of food additives under section 409(b) of the Federal Food, Drug, and Cosmetic Act. Petitioners must submit detailed information on the additive's chemical identity, composition, manufacturing process, analytical controls, stability data, and safety assessments to the FDA's Office of Food Additive Safety. Submissions must be in triplicate (or quadruplicate for meat/poultry uses) with English translations of foreign materials and supporting documentation.
Indirect Food Additives: General
21 CFR Part 174 establishes general regulatory provisions for indirect food additives—substances used in food-contact articles such as packaging and processing equipment. It defines good manufacturing practice requirements, including limits on additive migration into food and purity standards for components. The regulation permits use of substances generally recognized as safe, those with prior approval, and those meeting negligible migration thresholds, provided they comply with all applicable Federal Food, Drug, and Cosmetic Act provisions.
Secondary Direct Food Additives Permitted in Food for Human Consumption
21 CFR Part 173 establishes permitted secondary direct food additives for human consumption, including polymer substances and adjuvants. The regulation specifies acrylate-acrylamide resins, modified polyacrylamide resins, and ion-exchange membranes as safe food processing additives with defined usage limits and residual monomer restrictions. Acrylamide-based resins are approved as flocculents in sugar juice clarification and scale control, while ion-exchange membranes are permitted for juice processing and pH adjustment.
Food Additives
21 CFR Part 170 establishes regulatory definitions and general provisions governing food additives under the Federal Food, Drug, and Cosmetic Act. A food additive is any substance not exempted by law whose intended use may result in it becoming a component of food or affecting food characteristics, including substances in food contact articles and packaging materials. The regulation defines key terms including food contact substances, common use in food, and safety standards requiring reasonable certainty of harmlessness under conditions of intended use, determined through scientific procedures or general recognition of safety.
1,2-Dichloropropane (1,2-DCP); 1,1,2-Trichloroethane (1,1,2-TCA); Trans-1,2-Dichloroethylene (tDCE); 4,4′-(1-Methylethylidene)bis[2, 6-Dibromophenol] (TBBPA); and Ethylene Dibromide (EDB); Draft Hazard and Exposure Assessments; Science Advisory Committee on Chemicals (SACC) Peer Review; Notice of SACC Meeting; Availability of Draft Documents and Request for Comment
The Environmental Protection Agency (EPA or Agency) is announcing two virtual public meetings of the Science Advisory Committee on Chemicals (SACC). The first is a preparatory meeting scheduled for July 23, 2026. During the meeting, the SACC will consider the scope and clarity of the draft charge questions for the peer review of the draft technical support documents for 1,2-dichloropropane (1,2- DCP), 1,1,2-trichloroethane (1,1,2-TCA), trans-1,2-dichloroethylene (tDCE), 4,4'-(1-Methylethylidene)bis[2, 6-dibromophenol] (TBBPA), and ethylene dibromide (EDB). The second is the virtual SACC peer review meeting which will be held August 3 through 7, 2026, for the SACC to consider the draft technical support documents for 1,2-DCP, 1,1,2-TCA, tDCE, TBBPA, and EDB, and public comments on those materials. EPA is also announcing the availability of and soliciting public comment on the draft documents and charge questions that will be provided to the SACC for this peer review. The draft technical support documents were prepared under the Toxic Substances Control Act (TSCA) and will be submitted to the SACC for peer review.
Receipt of Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various Commodities-March 2026
This document announces the Agency's receipt of and solicits public comment on initial filings of pesticide petitions requesting the establishment or modification of regulations for residues of pesticide chemicals in or on various commodities. The Agency is providing this notice in accordance with the Federal Food, Drug, and Cosmetic Act (FFDCA). EPA uses the month and year in the title to identify when the Agency compiled the petitions identified in this notice of filing. Unit II. of this document identifies certain petitions received in 2024 and 2025 that are currently being evaluated by EPA, along with information about each petition, including who submitted the petition and the requested action.
EPCRA Hazardous Chemical Inventory Reporting Requirements: Conformity With the 2024 OSHA Hazard Communication Standard
The Environmental Protection Agency is conforming the Emergency Planning and Community Right-to-Know Act hazardous chemical inventory reporting regulations to the Occupational Safety and Health Administration's Hazard Communication Standard amendments of 2012 and 2024. The Emergency Planning and Community Right-to-Know Act (EPCRA) and its regulations rely on the Occupational Safety and Health Administration's (OSHA's) Hazard Communication Standard for the definition of a hazardous chemical and for the categories of health and physical hazards that must be reported under the hazardous chemical inventory regulations. This action conforms the terminology used and information that must be reported on the hazardous chemical inventory forms to the Hazard Communication Standard amendments. As a result, this action improves first responder and community safety, reduces discrepancies and confusion, prevents interpretation burdens on facilities when using (Material) Safety Data Sheets to complete annual hazardous chemical inventory reports, and enhances clarity.
Agency Information Collection Activities; Submission to the Office of Management and Budget for Review and Approval; Comment Request; Trade Secret Claims for Community Right-to-Know and Emergency Planning (Renewal)
The Environmental Protection Agency (EPA) has submitted an information collection request (ICR), Emergency Planning and Community Right-to-Know Act (EPCRA) Trade Secret Claims (EPA ICR Number 1428.13, OMB Control Number 2050-0078) to the Office of Management and Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act. This is a proposed extension of the ICR, which is currently approved through June 30, 2026. Public comments were previously requested via the Federal Register on December 11, 2025, during a 60-day comment period. This notice allows for an additional 30 days for public comments.
Pesticide Product Registration; Receipt of Applications for New Active Ingredients (March 2026)
This document announces the Agency's receipt of and solicits comments on applications to register pesticide products containing active ingredients not included in any currently registered pesticide products. The Agency is providing this notice in accordance with the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). EPA uses the month and year in the title to identify when the Agency complied with the applications identified in this notice of receipt. Unit II. of this document identifies certain applications received in 2024 and 2025 that are currently being evaluated by EPA, along with information about each application, including when it was received, who submitted the application, and the purpose of the application.
Joint Statement on Asbestos in Consumer Products
Joint Statement from OPSS, UKHSA and HSE.
Compliance with BAT-AELs for indirect emissions to water at chemical waste treatment installations: RPS 371
Environment Agency regulatory position on when you cannot comply with best available techniques associated emission limits (BAT-AELs) for certain substances discharged to sewer at chemical waste treatment installations.
Unavoidable Contaminants in Animal Food and Food-Packaging Material
21 CFR Part 509 establishes the regulatory framework for managing unavoidable contaminants in animal food and food-packaging materials. It defines naturally occurring versus added poisonous or deleterious substances, and authorizes the FDA to establish tolerances, regulatory limits, and action levels for contaminants. The regulation specifies procedures for setting contamination thresholds at which food is deemed adulterated and requires public notice and comment for action level changes.
Resin Acids, Esters With Glycerol in Pesticide Formulations; Exemption From the Requirement for a Tolerance
This regulation establishes an exemption from the requirement of a tolerance for residues of resin acids, esters with glycerol (CAS Reg. No. 8050-31-5) when used as an inert ingredient (surfactant) on growing crops and raw agricultural commodities pre- and post-harvest. Croda Inc. submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of resin acids, esters with glycerol when used in accordance with the terms of the exemption.
Waste: export and import
UK guidance on regulatory controls governing the transport of waste into and out of England, including documentation, permitting, and compliance requirements for waste exporters and importers.
United States Department of Justice and Parties to Certain Litigation; Transfer of Information Potentially Containing Confidential Business Information
The EPA will transfer pesticide-related information submitted under FIFRA and FFDCA to the DOJ and litigation parties, including data claimed as confidential business information, in accordance with CBI disclosure regulations.
4,4′-(1-Methylethylidene)bis[2,6-dibromophenol] (TBBPA) Risk Evaluation Under the Toxic Substances Control Act (TSCA); Notice of Availability and Request for Comment
EPA announces availability of and requests public comment on a draft risk evaluation for 4,4'-(1-Methylethylidene)bis[2,6-dibromophenol] (TBBPA) under the Toxic Substances Control Act. The evaluation will determine whether TBBPA presents unreasonable risk to human health or the environment under conditions of use, including risks to susceptible subpopulations, without considering costs.
Certain New Chemicals; Receipt and Status Information for February and March 2026
EPA announces receipt of new chemical submissions under TSCA for February-March 2026, including Premanufacture Notices (PMN), Significant New Use Notices (SNUN), Microbial Commercial Activity Notices (MCAN), biotechnology exemption applications, test marketing exemptions (TME), and notices of commencement of manufacture. The document provides status updates on chemicals under EPA review or recently concluded and invites public comment on submissions that passed initial screening.
Pesticide Product Registration; Receipt of Applications for New Uses (February 2026)
EPA announces receipt of applications to register new pesticide products containing currently registered active ingredients with changed use patterns, soliciting public comments per FIFRA requirements. The notice identifies applications evaluated in 2025, including submission dates, applicants, and intended uses.
Sodium Nitrate in Pesticide Formulations; Exemption From the Requirement of a Tolerance
EPA establishes an exemption from tolerance requirements for sodium nitrate residues used as an inert ingredient in pesticide fumigant canisters applied post-harvest to raw agricultural commodities in sealed warehouses under 40 CFR 180.910, eliminating the need to set maximum permissible residue levels. The regulation also corrects a typographical error in the CAS number for d-Alpha tocopherol.
Pydiflumetofen; Pesticide Tolerances
EPA establishes maximum permissible residue tolerances for pydiflumetofen on sugarcane and cane commodities. Syngenta Crop Protection petitioned under the FFDCA for these tolerance levels to permit lawful pesticide use on the specified food and feed crops.
DN31 2SY, Solenis UK Industries Limited: environmental permit surrender issued - EPR/KP3639QV/S003
Environmental permit surrender issued for Solenis UK Industries Limited (Grimsby Chemical Works, Grimsby) under the Industrial Emissions Directive (EPR/KP3639QV/S003).
Hazardous Materials: Notice of Applications for Modification to Special Permits
The Department of Transportation's Office of Hazardous Materials Safety has received applications for modification to special permits under hazardous materials regulations. This notice announces the initiation of review procedures for permit modifications.
Receipt of Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various Commodities-January 2026
EPA announces receipt of pesticide petitions for residue limits on various commodities and solicits public comment. The notice identifies petitions received in 2023-2025 currently under EPA evaluation, detailing submitters and requested regulatory actions, in accordance with the Federal Food, Drug, and Cosmetic Act.
Pesticide Product Registration; Receipt of Applications for New Uses (January 2026)
EPA announces receipt of applications to register new pesticide products containing currently registered active ingredients with changed use patterns under FIFRA. The notice solicits public comments on applications evaluated in 2023–2025, including submission dates, applicant identities, and intended uses.
Hazardous Materials: Notice of Applications for New Special Permits
The Department of Transportation's Office of Hazardous Materials Safety has received applications for special permits under the Hazardous Material Regulations. This notice announces the receipt of such applications and indicates the processing procedures that will be followed.
Hazardous Materials: Notice of Actions on Special Permits
The Department of Transportation's Office of Hazardous Materials Safety announces decisions on special permit applications for the transport of hazardous materials under DOT regulations. This notice documents grants or denials of permits requested by entities seeking exceptions or modifications to standard hazardous material shipping requirements.
Air Plan Approval; Connecticut; Ozone Ambient Air Quality Standard and Adhesive and Sealants Regulation Revisions
EPA approves Connecticut's State Implementation Plan revision aligning the state's ozone ambient air quality standard with federal NAAQS and clarifying volatile organic compound calculation methods for adhesive and sealant products under the Clean Air Act.
Technical Regulation for Detergents
Saudi Arabia's technical regulation for detergents establishes standards governing the composition, labeling, and safety requirements for detergent products. The regulation ensures consumer protection and environmental compatibility through specified chemical limits and performance criteria.
Technical regulation for Paints (Dyes) and Varnishes
Saudi Arabian technical regulation establishing standards for paints, dyes, and varnishes. The regulation sets requirements for composition, performance, and safety characteristics of paint and varnish products to ensure quality and compliance with national standards.
Technical Regulation for Building Materials: Part (1): Sectors of Metals and their Alloys ...
Saudi Arabian technical regulation establishing standards for building materials in the metals and metal alloys sector. Sets requirements for properties, testing, labeling, and quality assurance of metallic materials used in construction applications.
Technical Regulation for Gas Appliances and their Accessories
Saudi technical regulation establishing safety and performance standards for gas appliances and their accessories. Sets requirements for design, manufacture, testing, and labeling to ensure safe operation and consumer protection.
Technical Regulation for Degradable Plastic Products
Saudi Arabia's technical regulation establishes standards for degradable plastic products, defining performance requirements, testing methods, and labeling specifications to ensure environmental compatibility and product quality in the market.
Technical Regulation for Electronic Devices Used in Electronic Smoking Systems
Saudi Arabia's SASO technical regulation establishes standards for electronic devices used in electronic smoking systems, covering design, safety, performance, and component specifications to ensure product quality and user protection.
Technical Regulations for Limiting Hazardous Substances in Electrical and Electronic Devic...
Saudi Arabia's technical regulations establish limits on hazardous substances in electrical and electronic devices, aligning with international standards to restrict materials like lead, mercury, cadmium, and brominated flame retardants in manufacturing and product safety.
Technical Regulation for Electrical Batteries
Saudi Arabia's technical regulation establishes standards for electrical batteries, covering design, manufacturing, safety, performance, and labeling requirements to ensure product quality, consumer safety, and environmental protection in battery production and commerce.
Technical Regulation for Glue and Adhesive Materials
Saudi Arabian Standards Organization technical regulation establishing requirements and specifications for glue and adhesive materials, covering composition, performance, safety, and labeling standards for industrial and consumer applications.
Technical Regulations for Leather Products
Saudi Arabian Standards, Metrology and Quality Organization (SASO) technical regulations establishing standards for leather products, covering manufacturing specifications, quality requirements, and safety parameters applicable to leather goods production and trade.
Technical Regulation for Lubricating Oils
Saudi Arabian Standards Organization technical regulation establishing specifications and requirements for lubricating oils, covering quality, performance, testing, and safety criteria for mineral and synthetic lubricating oil products used in industrial, automotive, and mechanical applications.
Certain New Chemicals; Receipt and Status Information for November 2025, January 2026, and February 2026
EPA announces receipt of new chemical submissions under TSCA for February 2026, including Premanufacture Notices (PMNs), Significant New Use Notices (SNUNs), Microbial Commercial Activity Notices (MCANs), biotechnology exemption applications, test marketing exemptions, and notices of commencement of manufacture. The document provides status updates on chemicals under EPA review and offers opportunity for public comment.
Significant New Use Rules on Certain Chemical Substances (26-1)
EPA proposes significant new use rules (SNURs) under TSCA for certain chemical substances previously subject to premanufacture notices and EPA Orders. Manufacturers and processors must notify EPA 90 days before commencing manufacture, import, or processing of these chemicals for significant new uses. EPA review and determination must be completed before the new use activity can begin.
Definitions
21 CFR Part 1300 establishes definitions for controlled substances under the Controlled Substances Act and related regulations. Key definitions include anabolic steroids (controlled hormonal substances chemically related to testosterone), automated dispensing systems for medication management, and basic chemical classes of controlled substances. The regulation clarifies DEA authority and distinguishes between controlled substances and dietary ingredients or botanical compounds that are exempt from classification.
Substances Generally Recognized as Safe
21 CFR Part 582 establishes the regulatory framework for substances generally recognized as safe (GRAS) for use in food and animal feed. The regulation defines GRAS status, outlines good manufacturing and feeding practices including restrictions on quantities, and authorizes the FDA Commissioner to maintain lists of approved substances such as spices, essential oils, natural seasonings, and flavorings. Substances must be of appropriate grade and prepared as food ingredients, with quantities limited to what is reasonably necessary to accomplish their intended effect.
Administrative Functions, Practices, and Procedures
21 CFR Part 1316 establishes administrative inspection procedures under the Controlled Substances Act and Controlled Substances Import and Export Act. The regulation authorizes DEA inspectors to enter controlled premises to inspect records, verify inventory, collect samples, and examine equipment and materials related to controlled substances and listed chemicals manufacturing, distribution, and storage.
Labeling and Packaging Requirements for Controlled Substances
21 CFR Part 1302 establishes labeling and packaging requirements for controlled substances distributed in the United States. Manufacturers must print schedule symbols on commercial containers and labeling in a prominent, easily identifiable manner. Specific exemptions apply to containers too small to accommodate labels, clinical research involving blind studies, and exported substances. All containers must be sealed to detect tampering. These requirements apply to imported controlled substances but not to those intended for export.
Importation and Production Quotas for Ephedrine, Pseudoephedrine, and Phenylpropanolamine
21 CFR Part 1315 establishes procedures for setting annual importation and production quotas for ephedrine, pseudoephedrine, and phenylpropanolamine. The regulation applies to DEA-registered manufacturers and importers of these bulk chemicals and drug products, defines quota types including assessment of annual needs, individual manufacturing quotas, procurement quotas, and import quotas, and exempts personal imports not exceeding 7.5 grams per substance in any 30-day period.
Importation and Exportation of Controlled Substances
21 CFR Part 1312 establishes procedures for importation, exportation, and transshipment of controlled substances. Importers must obtain DEA authorization through registration and permits (for Schedules I-II and certain Schedule III-V substances) or import declarations (for other Schedule III-V substances). Each shipment requires separate authorization, and applicants must submit detailed information including drug names, dosage forms, NDC numbers, and quantities on DEA Form 357 through the DEA Diversion Control Division secure network.
Records and Reports of Listed Chemicals and Certain Machines; Importation and Exportation of Certain Machines
21 CFR Part 1310 establishes record-keeping and reporting requirements for regulated persons who handle DEA-designated listed chemicals and certain machines (tableting and encapsulating equipment). The regulation specifies two lists of chemicals subject to oversight, allows the DEA Administrator to add or remove substances via Federal Register notice, and requires manufacturers and distributors to maintain transaction records and file reports, particularly for ephedrine, pseudoephedrine, phenylpropanolamine, and gamma hydroxybutyric acid when shipped via postal or commercial carriers.
Food Additive Petitions
21 CFR Part 571 establishes the procedure for submitting food additive petitions to the FDA under the Federal Food, Drug, and Cosmetic Act. Petitioners must submit applications in triplicate with detailed information on the food additive's chemical identity, composition, manufacturing methods, analytical controls, stability data, and proposed uses. The regulation specifies content requirements including physical/chemical/biological properties, specifications, impurities, and manufacturing details for each entity involved in production.
Food Additives Permitted in Feed and Drinking Water of Animals
21 CFR Part 573 establishes permitted food additives for animal feed and drinking water. Regulations cover acrylamide-acrylic acid resin as a thickener/suspending agent in aqueous feed suspensions, aminoglycoside 3'-phosphotransferase II enzyme for genetic modification of crops, ammoniated cottonseed meal as a protein source in ruminant feed (max 20% of ration), and ammoniated rice hulls as fiber and nonprotein nitrogen source in beef cattle feed (max 20% of ration). Each additive includes specifications, approved uses, and labeling requirements for safe application.
Registration of Manufacturers, Distributors, Importers and Exporters of List I Chemicals
This regulation establishes registration requirements for manufacturers, distributors, importers, and exporters of List I chemicals under DEA jurisdiction. Registration is mandatory for entities handling ephedrine, pseudoephedrine, phenylpropanolamine, and other designated List I chemicals. Annual fees apply: $3,699 for manufacturers and $1,850 for distributors, importers, and exporters. Registration must be submitted online via the DEA's secure portal with payment by ACH transfer or credit card. Separate registrations are required for independent activities (manufacturing, distributing, importing, exporting).
Regulations Under the Federal Caustic Poison Act
21 CFR Part 1230 establishes labeling and packaging requirements for caustic and corrosive substances shipped in interstate or foreign commerce. Containers must bear clear labels with the common name of the dangerous substance, prominent "Poison" warnings in 24-point Gothic capitals, and directions for medical treatment in case of internal or external injury. Labeling must be firmly affixed and readily visible. Manufacturers, wholesalers, and distributors are responsible for compliance, with limited exemptions for non-household containers at shipment.
Retail Sale of Scheduled Listed Chemical Products
This regulation establishes requirements for retail sales of scheduled listed chemical products (ephedrine, pseudoephedrine, phenylpropanolamine) for personal use. It sets daily purchase limits (3.6 grams per substance per day), packaging requirements for nonliquid forms (blister packs or unit dose packets), and mandates loss reporting to the DEA within 15 days. Requirements apply to face-to-face retail sales and mail-order sales through regulated sellers and distributors.
Importation and Exportation of List I and List II Chemicals
21 CFR Part 1313 establishes procedures for importing, exporting, transshipping and in-transit shipment of List I and List II chemicals under the Chemical Diversion and Trafficking Act. Importers and exporters must notify the DEA at least 15 days before importing chemicals meeting threshold quantities, file declarations on DEA Form 486/486A, establish documented business relationships with customers, and maintain required records including supplier information and transaction frequency.
Intentional Genomic Alterations in Animals
21 CFR Part 528 establishes regulatory pathways for intentional genomic alterations in animals, including rabbits producing recombinant human Factor VII in milk for hemophilia treatment, genetically modified Atlantic salmon with enhanced growth rates in contained freshwater facilities, pigs with CD163 gene deletion conferring PRRSV resistance, pigs with modified GGTA1 gene for use as food or therapeutic sources, and chickens producing human lysosomal acid lipase for medical treatment. Food and feed restrictions apply to certain lineages.
Schedules of Controlled Substances
21 CFR Part 1308 establishes the schedules of controlled substances under the Controlled Substances Act, assigning DEA code numbers to opiates, opium derivatives, hallucinogenic substances, depressants, and other controlled drugs for identification and registration purposes. Applicants for procurement quotas, import/export permits, and registrants handling controlled substances must reference the appropriate code numbers on applications and declarations.
Food Additives
21 CFR Part 570 establishes regulatory definitions and provisions governing food additives under the Federal Food, Drug, and Cosmetic Act. It defines food additives as substances not exempted that become food components or affect food characteristics, including packaging materials with migration potential. The regulation outlines safety standards, requiring reasonable certainty of harmlessness based on scientific procedures, and addresses general recognition of safety, cumulative dietary effects, and prior sanctions.
Quotas
This regulation establishes procedures for DEA quotas on Schedule I and II controlled substances. It defines three quota types—aggregate production, individual manufacturing, and procurement—and five subcategories covering commercial sale, transfers, product development, and replacement of disposed material. Quotas limit the total and per-manufacturer quantities of controlled substance APIs that may be produced or procured annually for pharmaceutical manufacturing.
Substances Prohibited from Use in Animal Food or Feed
21 CFR Part 589 establishes prohibitions on substances in animal food and feed that present potential health risks or lack adequate safety data. The regulation prohibits gentian violet in all animal feed and propylene glycol in cat food, and restricts mammalian proteins in ruminant feed to prevent disease transmission. Violations render animal feed adulterated under the Federal Food, Drug, and Cosmetic Act.
Shredding waste upholstered domestic seating containing POPs: RPS 264
UK Environment Agency regulatory position on shredding waste upholstered domestic seating (WUDS) containing persistent organic pollutants (POPs). Addresses environmental controls and compliance requirements for waste management facilities handling upholstered furniture with POPs contamination.
TS2 1UB, Cumbria Waste Recycling Limited: environmental permit application advertisement - EPR/YP3424LH/A001
Environmental permit application advertisement by Cumbria Waste Recycling Limited for a hazardous waste transfer station at Seal Sands, Middlesborough, requiring regulatory approval under UK environmental permitting regulations.
Technical Regulation — Requirements for Electrical and Electronic Equipment
Saudi Arabia's mandatory technical regulation establishes safety, energy-efficiency, marking, and conformity-assessment requirements for electrical and electronic equipment sold domestically, covering design, manufacturing, labelling, and market surveillance.
Tracer tests and remediation schemes: environmental permit exemption
UK guidance on registration requirements for discharging small quantities of substances in groundwater tracer tests and remediation schemes conducted for scientific purposes, including exemptions from standard environmental permitting.
Certain New Chemicals; Receipt and Status Information for November 2025, December 2025, and January 2026
EPA announces receipt of new chemical submissions under TSCA for January 2026, including Premanufacture Notices (PMNs), Significant New Use Notices (SNUNs), Microbial Commercial Activity Notices (MCANs), biotechnology exemption applications, test marketing exemptions, and notices of commencement. The document provides status updates on chemicals under EPA review and invites public comment on all submitted notices.
Significant New Use Rules on Certain Chemical Substances (25-3.5e)
EPA proposes significant new use rules (SNURs) under TSCA for certain chemical substances previously subject to premanufacture notices and EPA Orders. Manufacturers and importers must notify EPA 90 days before manufacturing or processing these substances for significant new uses, and cannot commence such activities until EPA reviews the notification and makes an appropriate determination.
Alternative Electronic Submission of PCB Annual Reports
The EPA announces that facilities can now submit PCB Annual Reports electronically through the RCRAInfo system, replacing traditional submission methods. This shift to electronic reporting aims to reduce burden, lower costs, and improve administrative efficiency for regulated entities managing polychlorinated biphenyls.
Agency Information Collection Activities; Submission to the Office of Management and Budget for Review and Approval; Comment Request; PCBs, Consolidated Reporting and Recordkeeping Requirements (Revision)
The EPA submitted a revised information collection request (ICR 2668.03) for PCBs consolidated reporting and recordkeeping requirements to OMB for review under the Paperwork Reduction Act. The ICR is currently approved through February 28, 2027. This notice extends the public comment period for an additional 30 days following the initial 60-day comment period that closed in December 2025.
Applying for quota to produce or import F gas
UK guidance on applying for fluorinated gas (F gas) production and import quota in Great Britain, covering application procedures and timing requirements for regulatory compliance.
DY11 7QN, Hard Anodising Surface Treatments Ltd: environmental permit application advertisement - EPR/RP3324MS/A001
Environmental permit application advertisement for Hard Anodising Surface Treatments Ltd, a surface treatment facility in Kidderminster. The company is applying for an environmental permit to conduct hard anodising operations, a chemical surface treatment process subject to regulatory oversight under UK environmental permitting regulations.
1,2-dibromo-3-chloropropane; 1, 3-Butadiene; 13 Carcinogens (4-Nitrobiphenyl, etc.); Acrylonitrile; Asbestos; Benzene; Cadmium; Coke Oven Emissions; Cotton Dust; Ethylene Oxide; Formaldehyde; Inorganic Arsenic; Lead; Methylene Chloride; Methylenedianiline; Vinyl Chloride; Amending the Medical Evaluation Requirements in the Respiratory Protection Standard for Certain Types of Respirators; Safety Color Code for Marking Physical Hazards; Textiles; Sawmills; Safety Color Code for Marking Physical Hazards for Shipyard Employment; and Walking-Working Surfaces
OSHA is scheduling informal public hearings beginning August 19, 2026, on multiple proposed occupational safety rules covering carcinogenic substances (benzene, asbestos, vinyl chloride, formaldehyde, ethylene oxide, etc.), respiratory protection medical evaluations, safety color coding for physical hazards in general industry and shipyard employment, and walking-working surfaces standards. Most proposals were published July 1, 2025; the walking-working surfaces proposal was published April 6, 2026.
National Emission Standards for Hazardous Air Pollutants From Hazardous Waste Combustors: Residual Risk and Technology Review
EPA finalizes residual risk and technology review for hazardous waste combustor NESHAP, confirming existing standards adequately address HAP emissions and protect public health. New emission standards established for hydrogen fluoride and hydrogen cyanide from major source incinerators, cement kilns, and boilers. Final rule includes work practice standards for startup/shutdown/malfunction periods, electronic reporting requirements, and state permitting flexibility for area source HWCs.
Hazardous Materials: Streamlining Requirements for the Approval of Certain Energetic Materials
PHMSA amends Hazardous Materials Regulations to streamline approval processes for transporting low-hazard fireworks and small arms cartridges (including tracer ammunition) through simplified classification and self-classification options. The rule designates the PHMSA portal as the exclusive submission method for explosives approvals and permits approval holders to voluntarily terminate explosive approvals.
Pesticide Experimental Use Permit; Receipt of Application; Comment Request (March 2026)
EPA announces receipt of an experimental use permit (EUP) application from SUNY ESF for OxO American Chestnut, a genetically modified organism expressing oxalate oxidase to help combat chestnut blight. The agency has determined the permit may have regional and national significance and is soliciting public comments on the application.
Propylene Oxide; Pesticide Tolerances
EPA establishes pesticide residue tolerances for propylene oxide (PPO) on dried spices and seeds including sesame, turmeric, ginger, and peppers, following a petition from ABERCO, Inc. to set maximum permissible residue levels on these commodities.
Certain New Chemicals or Significant New Uses; Statements of Findings-March 2026
EPA publishes statements of findings on TSCA submissions (premanufacture notices, microbial commercial activity notices, and significant new use notices) reviewed during March 2026, documenting determinations that new chemical substances or significant new uses are not likely to present unreasonable risk to health or environment.
Significant New Use Rules on Certain Chemical Substances (25-2.5e)
EPA issues significant new use rules (SNURs) under TSCA for certain chemical substances previously subject to premanufacture notices and EPA orders. Manufacturers and importers must notify EPA at least 90 days before commencing manufacture or processing for designated significant new uses, and cannot proceed until EPA completes its review and determination.